Ingredients
Each hard gelatin capsule contains;
(as pellets)
| Mecobalamin (JP) | 1500mcg |
| Alpha Lipoic Acid (USP) | 200mg |
| Folic Acid (IP) | 1.5mg |
| Pyridoxine hydrochloride (Vit.B6) | 3.0mg |
| Biotin(BP) | 200mcg |
Indication
- Diabetic neuropathy
- Peripheral neuropathy
- Promoting nerve function
- Recovery of neuromuscular functions
Benefits
Folic Acid Folic acid’s primary mechanisms of action are through its role as a methyl donor in a range of metabolic and nervous system biochemical processes, as well as being necessary for DNA synthesis. With the help of the enzyme methionine synthase, mecobalamin donates a methyl group to the amino acid metabolite homocysteine, converting it to the amino acid methionine.
Pyridoxine Hydrochloride Pyridoxine depend enzymes are involved in a number of reactions such as decarboxylation of amino acids to yield amines, many of which are important neurotransmitters and hormones.
Biotin Biotin acts as a coenzyme for carbohydrate, fat, and protein metabolism. It is required for cell growth and production of fatty acids. It is required for healthy maintenance of hair, skin, sweat glands, nerve tissue, and bone marrow.
Pharmacokinetics
Mecobalamin Studies show that mecobalamin is utilized more efficiently than cyanocobalamin to increase levels of one of the coenzyme forms of vitamin B12. The quantity of cobalamin detected following a small oral dose of mecobalamin is similar to the amount following administration of cyanocobalamin. Human urinary excretion of mecobalamin is about one third that of a similar dose of cyanocobalamin, indicating substantially greater tissue retention.
Alpha lipoic Acid Alpha lipoic acid appears to be readily absorbed via the intestines from an oral dose and converts easily to its reduced form, dihydrolipoic acid (DHLA), in many tissues of the body. About 20-40% of oral alpha lipoic acid is absorbed from a dose of 200 mg. Alpha lipoic acid is excreted via renal elimination and has shown to cross the blood brain barrier.
Folic Acid Human pharmacokinetic studies indicate folic acid has very high bioavailability, with large oral doses of folic acid substantially raising plasma levels in healthy subjects in a time- and dose-dependent manner. Folic acid is poorly transported to the brain and rapidly cleared from the central nervous system. The primary methods of elimination of absorbed folic acid are faecal (through bile) and urinary.
Pyridoxine Hydrochloride Pyridoxine and its vitamers are absorbed in the upper small intestine by simple diffusion and transported to the liver for biotransformation into the active coenzyme pyridoxine 5 phosphate, which is then exported from the liver bound to albumin.
Biotin Following absorption, biotin is stored in the liver, kidney and pancreas.
Dosage & Administration
Adverse Reactions Mecobalamin, Alpha Lipoic Acid, Folic Acid, Pyridoxine Hydrochloride, Biotin hard gelatin capsules is generally well tolerated and adverse events are rare, including; Nausea, Itching, Ataxia, perioral numbness
Contraindications It is contraindicated if the user is known to be hypersensitivity to any of the ingredient in the formulation.
Precautions Mecobalamin should not be used over a period of months, if there is lack of satisfactory clinical response in patients with megaloblastic anaemia probably due to vitamin B12 deficiency or with peripheral neuropathies.
Storage
- Store in a cool, dry and dark place below 30°C or in air- conditioned area.
- Keep all medicine away from children.